Anti-Human Transferrin R/TfR Reference Antibody (Pabinafusp Alfa, RUO) (HY036016)

Name: Anti-Human Transferrin R/TfR Reference Antibody (Pabinafusp Alfa, RUO)
Brand: abinScience
SKU: HY036016
Price: 482 USD
Availability: InStock

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100ug
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Обзор

Каталожный номер	HY036016
Описание	Pabinafusp Alfa (HY036016) is a research-grade recombinant antibody targeting CD71. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1-kappa
Проверенные приложения	WB
Цель	CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17, IL17A, Interleukin-17A, ALB, Albumin, IL-13, IL13, Interleukin-13, NC30
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P02786
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	JR-141, 2140211-48-7
Фон	Transferrin receptor protein 1 (CD71/TFRC & IDS) is a ~84 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. 1. Senyilmaz, D. et al. (2015) Nature 525, 124-8. PMID: 26214738 2. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 26642240
Примечание	For research use only. Not suitable for clinical or therapeutic use.

Изображения

Bioactivity

Detects CD71/TFRC in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-CD71/TFRC monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD71/TFRC (Catalog No: HY036011)
Lane 2: negative control