Anti-Human EGFR & LGR5 Bispecific Reference Antibody (Petosemtamab, RUO) (HF004186)

Name: Anti-Human EGFR & LGR5 Bispecific Reference Antibody (Petosemtamab, RUO)
Brand: abinScience
SKU: HF004186
Price: 176 USD
Availability: InStock

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100ug
1mg
5mg
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100mg

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Даташит
SDS

Обзор

Каталожный номер	HF004186
Описание	Petosemtamab (HF004186) is a research-grade recombinant antibody targeting HER1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1-kappa
Проверенные приложения	FCM
Цель	EC:2.7.10.1, EGFR, ERBB, ERBB1, Epidermal growth factor receptor, HER1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, G protein-coupled receptor 49, G protein-coupled receptor 67, G protein-coupled receptor HG38, GPR49, GPR67, LGR5, Leucine-rich repeat-containing G protein-coupled receptor 5
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P00533 & O75473
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	Bispecific, MCLA-158, 2213450-26-9
Фон	Petosemtamab (MCLA 158) is an anti- EGFR (Kd: 0.22 nM) and anti-LGR5 (Kd: 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC).
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Изображения

Bioactivity

SEC-HPLC detection for Research Grade Petosemtamab.
SDS-PAGE

SDS-PAGE for Research Grade Petosemtamab.
Flow CytoMetry

Flow-cytometry using PE anti-human EGFR&LGR5 antibody. HepG-2 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human EGFR&LGR5 monoclonal antibody (Catalog: HF004186, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

Ссылки

Даташит

Anti-Human EGFR & LGR5 Bispecific Reference Antibody (Petosemtamab, RUO).pdf

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