Anti-Human CCR2 Reference Antibody (Plozalizumab, RUO) (HW392016)

Name: Anti-Human CCR2 Reference Antibody (Plozalizumab, RUO)
Brand: abinScience
SKU: HW392016
Price: 176 USD
Availability: InStock

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概要

カタログ番号	HW392016
説明	Plozalizumab (HW392016) is a research-grade recombinant antibody targeting CD192. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1-kappa
発現システム	Mammalian cells
ターゲット	CCR2, CC-CKR-2, C-C chemokine receptor type 2, CCR-2, C-C CKR-2, MCP-1-R, CMKBR2, CD192, Monocyte chemoattractant protein 1 receptor
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P41597
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	MLN-1202, anti-CCR2, hu1D9, 1610761-46-0
背景	C-C chemokine receptor type 2 (CD192/CCR2) is a ~41 kDa protein. Key functional receptor for CCL2 but can also bind CCL7, and CCL12. Also transduces signaling mediated by CCL13. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion. Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. 1. Tan, JHY. et al. (2013) The Journal of biological chemistry 288, 10024-10034. PMID: 23408426 2. Neehus, AL. et al. (2024) Cell 187, 390-408.e23. PMID: 38157855 3. Yamagami, S. et al. (1994) Biochemical and biophysical research communications 202, 1156-62. PMID: 8048929 4. Charo, IF. et al. (1994) Proceedings of the National Academy of Sciences of the United States of America 91, 2752-6. PMID: 8146186 5. De Paula, VS. et al. (2013) Journal of molecular biology 425, 4479-95. PMID: 23938203
注意事項	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Plozalizumab

参考文献

データシート

Anti-Human CCR2 Reference Antibody (Plozalizumab, RUO).pdf

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Anti-Human CCR2 Reference Antibody (Plozalizumab, RUO) (HW392016)

概要

イメージ

参考文献

データシート

SDS

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