Anti-Canine beta-NGF Reference Antibody (Ranevetmab, RUO) (CF909026)

Name: Anti-Canine beta-NGF Reference Antibody (Ranevetmab, RUO)
Brand: abinScience
SKU: CF909026
Price: 176 USD
Availability: InStock

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100ug
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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

CF909026

Description

Ranevetmab (CF909026) is a research-grade recombinant antibody targeting NGF/Beta-NGF. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Reactivité des espèces

Canine

Applications

ELISA, Bioactivity: FCM, Functional assay, Research in vivo

Espèce hôte

Canine

Clonalité

Monoclonal

Isotype

IgG1, kappa

Applications testées

Cible

Beta-NGF, Beta-nerve growth factor, NGF, NGFB

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

F1PDQ3

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Noms alternatifs

NV-01, 1632282-27-9

Contexte

Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs.
• Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair., PMID:37284244
• New insights of the role of β-NGF in the ovulation mechanism of induced ovulating species., PMID:30763273
• Effect of the Camelid's Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis., PMID:28713816
• β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis., PMID:28253191
• The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19., PMID:35095908
• HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy., PMID:38646645
• Heterologous beta-nerve growth factor (β-NGF) given at the LH surge enhances luteal function in dairy heifers., PMID:34186420
• β-NGF Stimulates Steroidogenic Enzyme and VEGFA Gene Expression, and Progesterone Secretion via ERK 1/2 Pathway in Primary Culture of Llama Granulosa Cells., PMID:33195615
• Ovulation mechanism in South American Camelids: The active role of β-NGF as the chemical signal eliciting ovulation in llamas and alpacas., PMID:32088046
• Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway., PMID:33179111

Note

For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

Detects Canine NGF in indirect ELISA.
SDS-PAGE

SDS-PAGE for Anti-Human beta-NGF Reference Antibody (Ranevetmab, RUO)
Western blot

Western blot analysis was performed using anti-dog NGF monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant dog NGF (Catalog No: CF909011)
Lane 2: negative control