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| カタログ番号 | FF909026 |
|---|---|
| 説明 |
Research Grade Relfovetmab (FF909026) is a felinized monoclonal antibody detecting Nerve Growth Factor beta subunit in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Cat.
Highlights
|
| 種反応性 | Feline |
| アプリケーション | ELISA, Bioactivity: FCM, Functional assay, Research in vivo |
| 宿主種 | Feline |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1-kappa |
| 発現システム | Mammalian cells |
| 性質 | Recombinant |
| ターゲット | Beta-NGF, Beta-nerve growth factor, NGF, NGFB |
| エンドトキシンレベル | < 10 EU/mg as determined by LAL method. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P01138 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ZTS-00084768, 2171034-70-9 |
| 背景 | Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a Kd of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats. • Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment., PMID:21358750 • Synthesis of the biologically active beta-subunit of human nerve growth factor in Escherichia coli., PMID:1537563 • Nerve growth factor translates stress response and subsequent murine abortion via adhesion molecule-dependent pathways., PMID:16371592 • Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes., PMID:2906326 • Nerve growth factor and the physiology of pain: lessons from congenital insensitivity to pain with anhidrosis., PMID:22882139 • A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception., PMID:14976160 • Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation., PMID:27146986 • Linkage relationships of the gene for the beta subunit of nerve growth factor (NGFB) with other chromosome 1 marker loci., PMID:4006521 • Nerve growth factor exhibits an antioxidant and an autocrine activity in mouse liver that is modulated by buthionine sulfoximine, arsenic, and acetaminophen., PMID:23472850 • Assignment of the beta-nerve growth factor (NGFB) to bovine chromosome 3 band q23 by in situ hybridization., PMID:9284944 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Anti-Human beta-NGF Reference Antibody (Relfovetmab, RUO)
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