Anti-Human Glypican 3 & TCRαβ & ALB Reference Antibody (SAR444200, RUO) (HW310086)

Name: Anti-Human Glypican 3 & TCRαβ & ALB Reference Antibody (SAR444200, RUO)
Brand: abinScience
SKU: HW310086
Price: 370 USD
Availability: InStock

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概要
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参考文献
データシート
SDS

概要

カタログ番号	HW310086
種反応性	Human
アプリケーション	Functional assay
クローン性	Monoclonal
アイソタイプ	VHH-VHH-VHH-VHH-His
ターゲット	GPC3, GTR2-2, Glypican-3, Glypican-3 alpha subunit, Glypican-3 beta subunit, Intestinal protein OCI-5, MXR7, OCI5
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
精製	Purified by Nickel column
アクセッション番号	P51654
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Glypican-3 (GPC3) is a ~65 kDa protein. Cell surface proteoglycan. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands. Positively regulates the non-canonical Wnt signaling pathway. 1. De Cat, B. et al. (2003) The Journal of cell biology 163, 625-35. PMID: 14610063 2. Capurro, MI. et al. (2005) The Journal of biological chemistry 280, 41201-6. PMID: 16227623 3. Capurro, M. et al. (2014) Journal of cell science 127, 1565-75. PMID: 24496449 4. Davoodi, J. et al. (2007) Proteomics 7, 2300-10. PMID: 17549790
注意事項	For research use only.