Anti-Human Complement Component C1s Reference Antibody (Sutimlimab, RUO) (HY598016)

Name: Anti-Human Complement Component C1s Reference Antibody (Sutimlimab, RUO)
Brand: abinScience
SKU: HY598016
Price: 176 USD
Availability: InStock

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100ug
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SDS

Обзор

Каталожный номер	HY598016
Описание	Sutimlimab (HY598016) is a research-grade recombinant antibody targeting C1 esterase. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG4-kappa
Система экспрессии	Mammalian cells
Цель	C1 esterase, Complement C1s subcomponent, C1S, Complement component 1 subcomponent s
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P09871
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	BIVV009, IPN-009, TNT009, 2049079-64-1
Фон	Complement C1s subcomponent is a ~76 kDa protein. Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway. 1. Lacroix, M. et al. (2001) The Journal of biological chemistry 276, 36233-40. PMID: 11445589 2. Kerr, FK. et al. (2005) The Journal of biological chemistry 280, 39510-4. PMID: 16169853 3. Kerr, MA. et al. (1978) The Biochemical journal 171, 99-107. PMID: 417728 4. Reboul, A. et al. (1979) FEBS letters 103, 156-61. PMID: 467643 5. McRae, BJ. et al. (1981) The Journal of biological chemistry 256, 12362-6. PMID: 6271784 6. Thielens, NM. et al. (1982) FEBS letters 141, 19-24. PMID: 6282646 7. Thielens, NM. et al. (1984) FEBS letters 165, 111-6. PMID: 6319179 8. Nagasawa, S. et al. (1977) Proceedings of the National Academy of Sciences of the United States of America 74, 2998-3001. PMID: 70787 9. Rossi, V. et al. (1998) The Journal of biological chemistry 273, 1232-9. PMID: 9422791 10. Zwarthoff, SA. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34155115
Примечание	For research use only. Not suitable for clinical or therapeutic use.

Изображения

Bioactivity

SEC-HPLC detection for Research Grade Sutimlimab.
SDS-PAGE

SDS-PAGE for Research Grade Sutimlimab.

Ссылки

Даташит

Anti-Human Complement Component C1s Reference Antibody (Sutimlimab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (Stock Conc.)

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