Anti-Human CCR8 Reference Antibody (Tagmokitug, RUO) (HW444066)

Name: Anti-Human CCR8 Reference Antibody (Tagmokitug, RUO)
Brand: abinScience
SKU: HW444066
Price: 176 USD
Availability: InStock

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Numéro de catalogue	HW444066
Description	tagmokitug (HW444066) is a research-grade recombinant antibody targeting CD198. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Reactivité des espèces	Human
Applications	ELISA, FACS, Functional assay
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, lambda2
Cible	CD198/CCR8
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P51685
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CAS: 3024486-14-1
Contexte	C-C chemokine receptor type 8 is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage. 1. Islam, SA. et al. (2013) The Journal of experimental medicine 210, 1889-98. PMID: 23999500 2. Ding, D. et al. (2022) Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 42, 19-28. PMID: 35041514
Note	For research use only.