Anti-Human Complement Component C1q Reference Antibody (Tanruprubart, RUO) (HY334026)

Name: Anti-Human Complement Component C1q Reference Antibody (Tanruprubart, RUO)
Brand: abinScience
SKU: HY334026
Price: 176 USD
Availability: InStock

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100ug
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概要
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概要

カタログ番号	HY334026
説明	tanruprubart (HY334026) is a research-grade recombinant antibody targeting C1q. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG4, Kappa
種	Human
ターゲット	C1q
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
アクセッション番号	P02745
形態	Liquid
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	2065212-40-8
背景	Complement C1q subcomponent subunit A is a ~26 kDa protein. Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system. 1. Kishore, U. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 171, 812-20. PMID: 12847249 2. Gadjeva, MG. et al. (2008) Biochemistry 47, 13093-102. PMID: 19006321 3. Diebolder, CA. et al. (2014) Science (New York, N.Y.) 343, 1260-3. PMID: 24626930 4. Ugurlar, D. et al. (2018) Science (New York, N.Y.) 359, 794-797. PMID: 29449492 5. Duncan, AR. et al. (1988) Nature 332, 738-40. PMID: 3258649 6. Zwarthoff, SA. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34155115 7. Lin, TY. et al. (1980) The Journal of biological chemistry 255, 7756-62. PMID: 6249812 8. Burton, DR. et al. (1980) Nature 288, 338-44. PMID: 6776418
注意事項	For research use only. Not suitable for clinical or therapeutic use.