Research Grade Tenecteplase (HF934016)

Name: Research Grade Tenecteplase
Brand: abinScience
SKU: HF934016
Price: 740 USD
Availability: InStock

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Precio(USD):

Especificación:

100ug
1mg

Número:

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Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HF934016

Reactividad de especies

Human

Aplicaciones

ELISA, Functional assay, Research in vivo

Clonalidad

Monoclonal

Actividad biológica

Alteplase (8.3 and 250 ug/mL, 12 h) shows a signifcant reduction in viability of human fetal retinal pigment epithelial (hfRPE cells) [4]. Alteplase (8.3 and 250 ug/mL, 0-6 h) signifcantly decreases the transepithelial resistance in a time-dependent manner and induces cell death in hfRPE cells [4]. Alteplase (0.9-10 mg/kg, i.v.

Sistema de expresión

Mammalian cells

Objetivo

t-plasminogen activator, tPA, t-PA, Reteplase, Tissue-type plasminogen activator, Alteplase, PLAT

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% purity as determined by SDS-PAGE.

Purificación

Purified by ion exchange chromatography.

Número de acceso

P00750

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Nombres alternativos

Tnkase, Dp00031, TNK-tPA, Metalyse, 191588-94-0

Fondo

Tissue-type plasminogen activator (PLAT/tPA) is a ~62 kDa protein. Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy.

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Referencias

1. J Bastecký, et al. [Actilyse (a recombinant tissue-type plasminogen activator] in the treatment of acute myocardial infarct. Comparison of the effects of Actilyse and streptokinase]. Vnitr Lek. 1994 May;40(5):293-8. [HF934016]
2. Micieli G, et al. Safety and efficacy of alteplase in the treatment of acute ischemic stroke. Vasc Health Risk Manag. 2009;5(1):397-409. [HF934016]
3. Orset C, et al. Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis. Stroke. 2016 May;47(5):1312-1318. [HF934016]
4. Kimura S, et al. Cytotoxic effects of alteplase, a recombinant tissue plasminogen activator, on human retinal pigment epithelial cells. Jpn J Ophthalmol. 2021 Sep;65(5):731-739. View More [HF934016]

Nota

For research use only. Not suitable for clinical or therapeutic use.

Imágenes

SDS-PAGE

SDS-PAGE for Research Grade Tenecteplase

Referencias

Datasheet

Research Grade Tenecteplase.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Research Grade Tenecteplase (HF934016)

Vista general

Imágenes

Referencias

Datasheet

SDS

Acceso rápido

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