Anti-Human Axl Reference Antibody (Tilvestamab, RUO) (HB709026)

Name: Anti-Human Axl Reference Antibody (Tilvestamab, RUO)
Brand: abinScience
SKU: HB709026
Price: 176 USD
Availability: InStock

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100ug
1mg
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Referencias
Datasheet
SDS

Vista general

Número de catálogo	HB709026
Descripción	Tilvestamab (HB709026) is a research-grade recombinant antibody targeting UFO. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-kappa
Sistema de expresión	Mammalian cells
Aplicaciones probadas	FCM
Objetivo	UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO, AXL
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P30530
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	Ab-2, BGB-149, 2226775-26-2
Fondo	Tyrosine-protein kinase receptor UFO (AXL) is a ~98 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase.
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)

Imágenes

Bioactivity

SEC-HPLC detection for Research Grade Tilvestamab.
SDS-PAGE

SDS-PAGE for Research Grade Tilvestamab.
Flow CytoMetry

Flow-cytometry using APC anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using PE anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using FITC anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.