Anti-Human Axl Reference Antibody (Tilvestamab, RUO) (HB709026)

Name: Anti-Human Axl Reference Antibody (Tilvestamab, RUO)
Brand: abinScience
SKU: HB709026
Price: 176 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HB709026
Description	Tilvestamab (HB709026) is a research-grade recombinant antibody targeting UFO. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-kappa
Système d'expression	Mammalian cells
Applications testées	FCM
Cible	UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO, AXL
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P30530
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	Ab-2, BGB-149, 2226775-26-2
Contexte	Tyrosine-protein kinase receptor UFO (AXL) is a ~98 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)

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Bioactivity

SEC-HPLC detection for Research Grade Tilvestamab.
SDS-PAGE

SDS-PAGE for Research Grade Tilvestamab.
Flow CytoMetry

Flow-cytometry using APC anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using PE anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using FITC anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.