Anti-Human Axl Reference Antibody (Tilvestamab, RUO) (HB709026)

Name: Anti-Human Axl Reference Antibody (Tilvestamab, RUO)
Brand: abinScience
SKU: HB709026
Price: 176 USD
Availability: InStock

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100ug
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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HB709026
説明	Tilvestamab (HB709026) is a research-grade recombinant antibody targeting UFO. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1-kappa
発現システム	Mammalian cells
テスト済みアプリケーション	FCM
ターゲット	UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO, AXL
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P30530
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	Ab-2, BGB-149, 2226775-26-2
背景	Tyrosine-protein kinase receptor UFO (AXL) is a ~98 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase.
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)

イメージ

Bioactivity

SEC-HPLC detection for Research Grade Tilvestamab.
SDS-PAGE

SDS-PAGE for Research Grade Tilvestamab.
Flow CytoMetry

Flow-cytometry using APC anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using PE anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using FITC anti-human AXL antibody. U251 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human AXL monoclonal antibody (Catalog: HB709026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.