Anti-Human CD27 Ligand/TNFSF7/CD70 Reference Antibody (Tixestobart, RUO) (HB796056)

Name: Anti-Human CD27 Ligand/TNFSF7/CD70 Reference Antibody (Tixestobart, RUO)
Brand: abinScience
SKU: HB796056
Price: 370 USD
Availability: InStock

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100ug
1mg
5mg
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Número de catálogo	HB796056
Descripción	tixestobart (HB796056) is a research-grade recombinant antibody targeting CD27. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	Human IgG1, lambda2
Especies	Human
Objetivo	CD27
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Número de acceso	P26842
Forma	Liquid
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	2733575-82-9
Fondo	CD27 antigen is a ~29 kDa protein. Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue. 1. Izawa, K. et al. (2017) The Journal of experimental medicine 214, 73-89. PMID: 28011863 2. Jaeger-Ruckstuhl, CA. et al. (2024) Immunity 57, 287-302.e12. PMID: 38354704
Nota	For research use only. Not suitable for clinical or therapeutic use.