Anti-Human CD282/TLR2 Reference Antibody (Tomaralimab, RUO) (HT188016)

Name: Anti-Human CD282/TLR2 Reference Antibody (Tomaralimab, RUO)
Brand: abinScience
SKU: HT188016
Price: 176 USD
Availability: InStock

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Numéro de catalogue	HT188016
Description	Research Grade Tomaralimab (HT188016) is a monoclonal antibody.
Applications	ELISA, FACS, Functional assay, antagonist
Clonalité	Monoclonal
Cible	CD282, TIL4, TLR2, Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	O60603
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Toll-like receptor 2 is a ~89 kDa protein. Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. 1. Jin, MS. et al. (2007) Cell 130, 1071-82. PMID: 17889651 2. Lancioni, CL. et al. (2011) Infection and immunity 79, 663-73. PMID: 21078852 3. Brightbill, HD. et al. (1999) Science (New York, N.Y.) 285, 732-6. PMID: 10426995 4. Aliprantis, AO. et al. (1999) Science (New York, N.Y.) 285, 736-9. PMID: 10426996 5. Bulut, Y. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 987-94. PMID: 11441107 6. Jung, SB. et al. (2006) Infection and immunity 74, 2686-96. PMID: 16622205 7. Drage, MG. et al. (2009) Cellular immunology 258, 29-37. PMID: 19362712 8. Bulut, Y. et al. (2005) The Journal of biological chemistry 280, 20961-7. PMID: 15809303 9. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 16880211
Note	For research use only.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)