Research Grade Trebananib (HT073096)

Name: Research Grade Trebananib
Brand: abinScience
SKU: HT073096
Price: 320 USD
Availability: InStock

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概要
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概要

カタログ番号	HT073096
説明	Trebananib (HT073096) is a research-grade recombinant antibody targeting ANG-2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Functional assay, Research in vivo
宿主種	Human
アイソタイプ	Fusion - IGHG1 Fc (Fragment constant) - [peptide 14-mer - peptide 14-mer]2
発現システム	Mammalian cells
ターゲット	ANG-2, ANGPT2, Angiopoietin-2
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	O15123
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	2xCon4C, AMG386
背景	Angiopoietin-2 (ANGPT2/ANG-2) is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis. 1. Lee, HJ. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1200-8. PMID: 15284220 2. Yacyshyn, OK. et al. (2009) Angiogenesis 12, 25-33. PMID: 19116766 3. Yuan, HT. et al. (2009) Molecular and cellular biology 29, 2011-22. PMID: 19223473 4. Maisonpierre, PC. et al. (1997) Science (New York, N.Y.) 277, 55-60. PMID: 9204896 5. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)