Protein A/G purified from cell culture supernatant.
Номер доступа
P05112
Форма
Liquid
Буфер хранения
0.01M PBS pH 7.4.
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Информация об использовании продукта
Применение
Разбавление
WB
1:500-1:2000
Устойчивость и хранение
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия
VAK-694, NVP-VAK-694
Фон
Interleukin-4 (IL4) is a ~17 kDa protein. Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
1. Carr, C. et al. (1991) Biochemistry 30, 1515-23. PMID: 1993171
2. Yokota, T. et al. (1986) Proceedings of the National Academy of Sciences of the United States of America 83, 5894-8. PMID: 3016727
3. Delespesse, G. et al. (1989) Journal of immunology (Baltimore, Md. : 1950) 142, 134-8. PMID: 2521231
4. Hage, T. et al. (1999) Cell 97, 271-81. PMID: 10219247
5. Hülsmeyer, M. et al. (2001) Acta crystallographica. Section D, Biological crystallography 57, 1334-6. PMID: 11526337
6. LaPorte, SL. et al. (2008) Cell 132, 259-72. PMID: 18243101
7. Malabarba, MG. et al. (1995) The Journal of biological chemistry 270, 9630-7. PMID: 7721895
Ссылки
1. Koneczny I, et al. IgG4 Autoantibodies in Organ-Specific Autoimmunopathies: Reviewing Class Switching, Antibody-Producing Cells, and Specific Immunotherapies. Front Immunol. 2022;13:834342. Published 2022 Mar 24. [HY457026] 2. Pfaar O, et al. Anti-IgE: A treatment option in allergic rhinitis?. Allergol Select. 2021;5:119-127. Published 2021 Feb 24. [HY457026]
Примечание
For research use only. Not suitable for clinical or therapeutic use.
Detects recombinant IL4 (Catalog No: HY457021) in indirect ELISA.
Western blot
Western blot analysis was performed using anti-IL4 monoclonal antibody at 1ug/mL on various samples. Lane 1: recombinant human IL4 (Catalog No: HY457021) Lane 2: Negative control
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