Research Grade Velaglucerase Beta (HY292016)

Name: Research Grade Velaglucerase Beta
Brand: abinScience
SKU: HY292016
Price: 370 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HY292016
Reactivité des espèces	Human
Applications	ELISA, Functional assay, Research in vivo
Isotype	Human lysosomal acid glucosylceramidase
Système d'expression	Mammalian cells
Cible	SGTase, Cholesterol glucosyltransferase, GBA, Cholesteryl-beta-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, GLUC, Imiglucerase, Beta-glucocerebrosidase, Lysosomal acid GCase, Beta-GC, Alglucerase, GC, Lysosomal acid glucosylceramidase, Acid beta-glucosidase
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P04062
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	2725857-55-4
Contexte	Lysosomal acid glucosylceramidase (GBA) is a ~59 kDa protein. Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose. Plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol. GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine). 1. Ron, I. et al. (2005) Blood cells, molecules & diseases 35, 57-65. PMID: 15916907 2. Akiyama, H. et al. (2013) Biochemical and biophysical research communications 441, 838-43. PMID: 24211208 3. Akiyama, H. et al. (2020) The Journal of biological chemistry 295, 5257-5277. PMID: 32144204 4. Bannink, S. et al. (2024) Journal of lipid research 65, 100670. PMID: 39395789 5. Vaccaro, AM. et al. (1997) The Journal of biological chemistry 272, 16862-7. PMID: 9201993 6. Magalhaes, J. et al. (2016) Human molecular genetics 25, 3432-3445. PMID: 27378698 7. Kitatani, K. et al. (2009) The Journal of biological chemistry 284, 12972-8. PMID: 19279011 8. Marques, AR. et al. (2016) Journal of lipid research 57, 451-63. PMID: 26724485 9. Boer, DE. et al. (2021) Journal of lipid research 62, 100018. PMID: 33361282
Reférences	1. Neal J Weinreb, et al. Imiglucerase and its use for the treatment of Gaucher's disease. Expert Opin Pharmacother. 2008 Aug;9(11):1987-2000. [HY292016]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Velaglucerase Beta

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Research Grade Velaglucerase Beta.pdf

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