Anti-Human ADCYAP1/PACAP Reference Antibody (Vipalanebart, RUO) (HB716036)

Name: Anti-Human ADCYAP1/PACAP Reference Antibody (Vipalanebart, RUO)
Brand: abinScience
SKU: HB716036
Price: 370 USD
Availability: InStock

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100ug
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Número de catálogo	HB716036
Descripción	Vipalanebart (HB716036) is a research-grade recombinant antibody targeting Pituitary adenylate cyclase-activating polypeptide. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human, Mouse
Aplicaciones	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG4-kappa
Sistema de expresión	Mammalian cells
Naturaleza	Recombinant
Aplicaciones probadas	WB
Objetivo	Pituitary adenylate cyclase-activating polypeptide, ADCYAP1, PACAP, PACAP-38, PACAP38, PACAP-27, PACAP27, PRP-48
Nivel de endotoxinas	< 10 EU/mg as determined by LAL method.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P18509, O70176
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	LY 3451838, LY-3451838, LY3451838, CAS: 2642173-04-2
Fondo	Pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells. 1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907 2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469 3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270 4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)

Imágenes

SDS-PAGE

SDS-PAGE for Research Grade Vipalanebart.
Bioactivity

Detects recombinant mouse ADCYAP1 (Catalog No: MB716012) in indirect ELISA.
Western blot

Lane 1: recombinant mouse ADCYAP1 (Catalog No: MB716012)
Lane 2: 1*loading buffer

Referencias

Datasheet

Anti-Human ADCYAP1/PACAP Reference Antibody (Vipalanebart, RUO).pdf

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Anti-Human ADCYAP1/PACAP Reference Antibody (Vipalanebart, RUO) (HB716036)

Vista general

Imágenes

Referencias

Datasheet

SDS