Anti-Human PAC1R Reference Antibody (Zelminemab, RUO) (HW609016)

Name: Anti-Human PAC1R Reference Antibody (Zelminemab, RUO)
Brand: abinScience
SKU: HW609016
Price: 176 USD
Availability: InStock

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Спецификация:

100ug
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SDS

Обзор

Каталожный номер	HW609016
Описание	Zelminemab (HW609016) is a research-grade recombinant antibody targeting ADCYAP1R1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1-kappa
Система экспрессии	Mammalian cells
Цель	ADCYAP1R1, PACAP-R-1, PACAP type I receptor, Pituitary adenylate cyclase-activating polypeptide type I receptor, PACAP-R1
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P41586
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	AMG-301, 2225850-33-7
Фон	Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1) is a ~53 kDa protein. G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. 1. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270 2. Hu, E. et al. (2021) Journal of medicinal chemistry 64, 3427-3438. PMID: 33715378 3. Xu, Y. et al. (2022) Nature communications 13, 2272. PMID: 35477937 4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Anti-LASV GPC Recombinant Antibody (Fab 37.7) (VK453013)

Изображения

Bioactivity

SEC-HPLC detection for Research Grade Zelminemab.
SDS-PAGE

SDS-PAGE for Research Grade Zelminemab.

Ссылки

Даташит

Anti-Human PAC1R Reference Antibody (Zelminemab, RUO).pdf

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