Oropouche Virus (OROV) Research Reagents — Antibodies & Recombinant Proteins

Glycoprotein Gn (G1) — Receptor Binding & Neutralization Target
Gn mediates viral attachment to host cells and is the primary target for neutralizing antibodies. abinScience provides the deepest anti-OROV Gn panel available — including 4 nanobody clones for epitope mapping and therapeutic development:
• Anti-Gn nanobodies: VK008043, VK008013, VK008023, and VK008033 — small single-domain antibodies ideal for diagnostic lateral flow, intracellular targeting, and combination epitope coverage
• Recombinant Gn proteins: C-Fc (VK008021), C-His (VK008041), N-His (VK008042), and N-GST&C-His (VK008032) — four tag formats for ELISA development, SPR binding, and immunogen evaluation
• Anti-Gn polyclonal antibody (VK008044)

Glycoprotein Gc (G2) — Fusion Protein
Gc is the class II fusion glycoprotein that mediates low-pH-triggered membrane fusion in endosomes. Available: recombinant Gc proteins — N-His (VK008022) and C-His (VK008031); and anti-Gc polyclonal antibody (VK008024).

Nucleoprotein (NP) — Diagnostic Antigen
NP is the most abundant viral protein and the standard target for OROV serological assays (IgM/IgG ELISA) and antigen-capture diagnostics. NP-based ELISA is currently the most accessible diagnostic approach for OROV, given the limited availability of commercial RT-PCR kits. Available: recombinant NP protein N-His (VK008012) and anti-NP polyclonal antibody (VK008014).

Why is OROV suddenly getting attention in 2024?
OROV underwent unprecedented geographic expansion in 2024, spreading beyond its traditional Amazonian endemic zone to major urban centers in Brazil and producing travel-associated cases in Europe and North America. This expansion, combined with the first documented cases of vertical transmission (congenital OROV) and potential neurological complications, has elevated OROV as a global surveillance priority. There are currently no approved vaccines or antivirals for OROV.

Which reagents are best for building an OROV diagnostic ELISA?
For IgM/IgG serology: use NP protein N-His (VK008012) as the coating antigen — NP is the most immunogenic OROV protein and elicits early IgM responses. For antigen-capture ELISA: pair the anti-NP pAb (VK008014) as capture with a labeled detection antibody, or use Gn C-Fc (VK008021) for Gn-based detection.

Do your OROV nanobodies cross-react with other bunyaviruses?
OROV Gn shares limited sequence identity with other peribunyaviruses (Bunyamwera, Schmallenberg). Cross-reactivity of our anti-Gn nanobodies with related viruses has not been established. Contact us for cross-reactivity testing. For CCHFV and RVFV (different bunyavirus genera), see our dedicated pages.

Explore reagents for related arboviruses and bunyaviruses:

OROV ✓ CCHFV Rift Valley fever (RVFV) SFTSV Hantavirus Dengue (DENV) CHIKV