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| 카탈로그 번호 | HW527014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 이소타입 | IgG | ||||||||
| 클론성 | Polyclonal | ||||||||
| 면역원 | E. coli - derived recombinant Human VHL (Glu70-Asp213). | ||||||||
| 타겟 | VHL, pVHL, Protein G7, von Hippel-Lindau disease tumor suppressor | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P40337 | ||||||||
| RRID | Anti-Human VHL Polyclonal Antibody (abinScience Cat# HW527014, RRID:AB_3731117) |
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| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | von Hippel-Lindau disease tumor suppressor (VHL) is a ~24 kDa protein. Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR. 1. Tanimoto, K. et al. (2000) The EMBO journal 19, 4298-309. PMID: 10944113 2. Cheng, J. et al. (2007) Cell 131, 584-95. PMID: 17981124 3. Xie, L. et al. (2009) Science signaling 2, ra33. PMID: 19584355 4. Ganner, A. et al. (2021) Scientific reports 11, 14827. PMID: 34290272 | ||||||||
| 참고사항 | For research use only. |
Western blot analysis was performed using anti-Human VHL polyclonal antibody at 1ug/mL on recombinant Human VHL (Catalog No. HW527012).
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