Anti-Human S100A9 Antibody (6B4) (HY562013)

데이터시트 제품 공유 정보 복사

가격(USD): $

사양:

20ug
50ug
100ug
1mg

수량:

문의하기

개요
이미지
참고 문헌
데이터시트

개요

카탈로그 번호

HY562013

설명

Anti-Human S100A9 Antibody (6B4) [6B4] (HY562013) is a mouse monoclonal antibody detecting S100A9 in ELISA, FCM, WB. Suitable for Human.

Highlights

●Multi-Application — Validated across multiple applications.
●Flow Cytometry — Validated for flow cytometry applications.

종 반응성

Human

응용 분야

ELISA, FCM, WB

숙주 종

Mouse

이소타입

IgG2a, kappa

클론 ID

6B4

클론성

Monoclonal

타겟

Protein S100-A9, CAGB, MRP-14, S100 calcium-binding protein A9, Leukocyte L1 complex heavy chain, Migration inhibitory factor-related protein 14, p14, Calprotectin L1H subunit, S100A9, Calgranulin-B, CFAG, MRP14

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

P06702

RRID

Anti-Human S100A9 Antibody (6B4) (abinScience Cat# HY562013, RRID:AB_3726893)

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

배경

Protein S100-A9 (S100A9) is a ~13 kDa protein. S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Also participates in regulatory T-cell differentiation together with CD69.

1. Ryckman, C. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 170, 3233-42. PMID: 12626582

2. Vogl, T. et al. (2004) Blood 104, 4260-8. PMID: 15331440

3. Nakatani, Y. et al. (2005) Mediators of inflammation 2005, 280-92. PMID: 16258195

4. Champaiboon, C. et al. (2009) The Journal of biological chemistry 284, 7078-90. PMID: 19122197

5. Simard, JC. et al. (2010) Journal of leukocyte biology 87, 905-14. PMID: 20103766

6. Simard, JC. et al. (2011) Journal of immunology (Baltimore, Md. : 1950) 186, 3622-31. PMID: 21325622

7. Miyasaki, KT. et al. (1993) Journal of dental research 72, 517-23. PMID: 8423249

8. Lin, CR. et al. (2015) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29, 5006-17. PMID: 26296369

참고사항

For research use only.

이미지

Bioactivity

Detects Recombinant Human S100A9 Protein, N-His (Cat No.: HY562012) in indirect ELISA.
SDS-PAGE

SDS-PAGE for Anti-Human S100A9 Antibody (6B4).