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| 카탈로그 번호 | HB732013 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Human CD124/IL4R/IL-4Rα Nanobody (SAA1420) [SAA1420] (HB732013) is a alpaca monoclonal antibody detecting IL-4R-alpha in ELISA. Suitable for Human.
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| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Alpaca | ||||
| 이소타입 | VHH-8His-Cys-tag | ||||
| 클론 ID | SAA1420 | ||||
| 클론성 | Monoclonal | ||||
| 타겟 | IL-4RA, IL-4-binding protein, IL-4 receptor subunit alpha, Soluble IL-4R-alpha, IL4-BP, IL4R, IL-4R subunit alpha, IL-4R-alpha, CD124, Interleukin-4 receptor subunit alpha, IL4RA, Soluble IL-4 receptor subunit alpha, sIL4Ralpha/prot | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Purified by Nickel column. | ||||
| 등록번호 | P24394 | ||||
| RRID | Anti-Human CD124/IL4R/IL-4Rα Nanobody (SAA1420) (abinScience Cat# HB732013, RRID:AB_3726926) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS, pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Interleukin-4 receptor subunit alpha (CD124/IL4R) is a ~89 kDa protein. Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. CD124 is the therapeutic target of dupilumab (Dupixent). 1. Andrews, AL. et al. (2006) The Journal of allergy and clinical immunology 118, 858-65. PMID: 17030238 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human CD124/IL4R/IL-4Rα Nanobody (SAA1420)
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