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Anti-Human NKG2A/CD159a Recombinant Antibody (S-095029) (HB188013)

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Vista general
Número de catálogoHB188013
Descripción
Anti-Human NKG2A/CD159a Recombinant Antibody (S-095029) (HB188013) is a human monoclonal antibody detecting NKG2A/CD159a in ELISA, FACS, Functional assay. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, FACS, Functional assay
Especie huéspedHuman
ClonalidadMonoclonal
IsotipoIgG1, kappa
ID de clonS-095029
Objetivo CD159 antigen-like family member A, CD159a, KLRC1, NK cell receptor A, NKG2-A/B-activating NK receptor, NKG2-A/NKG2-B type II integral membrane protein, NKG2A
Nivel de endotoxinas < 10 EU/mg as determined by LAL method.
Pureza >95% as determined by SDS-PAGE.
Purificación Protein A/G purified from cell culture supernatant.
Número de acceso P26715
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Información de uso del producto
Aplicación Dilución
ELISA 1:2000-1:20000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

NKG2-A/NKG2-B type II integral membrane protein (CD159a/KLRC1) is a ~26 kDa protein. Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions.

1. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576
2. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229
3. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220
4. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650
5. Kabat, J. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1948-58. PMID: 12165520
6. Le Dréan, E. et al. (1998) European journal of immunology 28, 264-76. PMID: 9485206
7. Kamiya, T. et al. (2019) The Journal of clinical investigation 129, 2094-2106. PMID: 30860984
8. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742
9. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301
Nota For research use only.
Isotype Control Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)
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Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human NKG2A/CD159a Recombinant Antibody (S-095029)

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