Anti-Human CD159a/KLRC1 Recombinant Antibody (13F3) (HB188207)

Name: Anti-Human CD159a/KLRC1 Recombinant Antibody (13F3)
Brand: abinScience
SKU: HB188207
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HB188207
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	13F3
Clonality	Monoclonal
Target	KLRC1, NKG2-A/NKG2-B type II integral membrane protein, NKG2-A/B-activating NK receptor, CD159 antigen-like family member A, CD159a, NK cell receptor A, NKG2A
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P26715
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	NKG2-A/NKG2-B type II integral membrane protein (CD159a/KLRC1) is a ~26 kDa protein. Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. 1. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576 2. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229 3. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220 4. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650 5. Kabat, J. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1948-58. PMID: 12165520 6. Le Dréan, E. et al. (1998) European journal of immunology 28, 264-76. PMID: 9485206 7. Kamiya, T. et al. (2019) The Journal of clinical investigation 129, 2094-2106. PMID: 30860984 8. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742 9. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301
Note	For research use only.

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Datasheet

Anti-Human CD159a/KLRC1 Recombinant Antibody (13F3).pdf

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Anti-Human CD159a/KLRC1 Recombinant Antibody (13F3) (HB188207)

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