Anti-Avelumab Non-Neutralizing Recombinant Antibody (SAA2914) (AV974133)

Name: Anti-Avelumab Non-Neutralizing Recombinant Antibody (SAA2914)
Brand: abinScience
SKU: AV974133
Price: 168 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	AV974133
Описание	Anti-Avelumab Non-Neutralizing Recombinant Antibody (SAA2914) (AV974133) is a mouse monoclonal antibody detecting Avelumab in ELISA. Suitable for General. Highlights ●Affinity Purified — Minimal background and high purity for reliable results.
Реактивность видов	General
Применения	ELISA
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1
ID клона	SAA2914
Иммуноген	Avelumab
Уровень эндотоксинов	< 10EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	CAS: 1537032-82-8
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Programmed cell death 1 ligand 1 (Avelumab) is a ~33 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis. 1. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443 2. Mezzadra, R. et al. (2017) Nature 549, 106-110. PMID: 28813410 3. Burr, ML. et al. (2017) Nature 549, 101-105. PMID: 28813417 4. Huang, X. et al. (2019) Cancer immunology research 7, 1580-1590. PMID: 31399419 5. Kennedy, A. et al. (2023) The EMBO journal 42, e111556. PMID: 36727298 6. Dong, H. et al. (1999) Nature medicine 5, 1365-9. PMID: 10581077 7. Hou, J. et al. (2020) Nature cell biology 22, 1264-1275. PMID: 32929201
Примечание	For research use only.