Anti-Avelumab Polyclonal Antibody (AV974024)

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Spec:

50ug
100ug
1mg

Number:

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SDS

Overview

Catalog No.

AV974024

Description

Anti-Avelumab Polyclonal Antibody (AV974024) is a rabbit polyclonal antibody detecting Avelumab in ELISA.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

Applications

ELISA

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

Avelumab

Target

Rabbit polyclonal to Bavencio.

Specificity

The product is specific for Avelumab. This antibody serves as an excellent positive control for Avelumab immunogenicity (ADA) assays.

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

CAS: 1537032-82-8

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

The product can be stored for 2 - 3 weeks at 2 to 8°C or for up to 12 months at -20°C. Avoid repeated freezing and thawing cycles.

Background

Avelumab with trade name Bavencio, is an FDA-approved drug to treat Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer. Inhibition of PD-L1 by Avelumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as

Note

For research use only.

Images

References

Datasheet

Anti-Avelumab Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Avelumab Polyclonal Antibody (AV974024)

Overview

Images

References

Datasheet

SDS

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