

| Каталожный номер | HW570014 | ||||||
|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human Notch-1 Polyclonal Antibody (HW570014) is a rabbit polyclonal antibody detecting Notch-1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||
| Применения | ELISA, IHC, WB | ||||||
| Хозяинский вид | Rabbit | ||||||
| Клоональность | Polyclonal | ||||||
| Изотип | IgG | ||||||
| Иммуноген | E. coli - derived recombinant NOTCH1 (Lys1759-Ala2127). | ||||||
| Цель | NEXT, NICD, NOTCH1, Neurogenic locus notch homolog protein 1, Notch 1, Notch 1 extracellular truncation, Notch 1 intracellular domain, TAN1, Translocation-associated notch protein TAN-1, hN1 | ||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||
| Очистка | Purified by antigen affinity column. | ||||||
| Номер доступа | P46531 | ||||||
| Форма | Liquid | ||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Реконституция | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||||
| Доставка | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||||
| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| Фон | Neurogenic locus notch homolog protein 1 (NOTCH1) is a ~272 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. | ||||||
| Примечание | For research use only. |




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