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| カタログ番号 | HV999014 | ||||||
|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human IL-22 Polyclonal Antibody (HV999014) is a rabbit polyclonal antibody detecting IL-22 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||
| アプリケーション | ELISA, IHC, WB | ||||||
| 宿主種 | Rabbit | ||||||
| クローン性 | Polyclonal | ||||||
| アイソタイプ | IgG | ||||||
| 免疫原 | E. coli - derived recombinant Human IL22 (Ala34-Ile179). | ||||||
| ターゲット | RecName: Full=Interleukin-22; Short=IL-22; AltName: Full=Cytokine Zcyto18; AltName: Full=IL-10-related T-cell-derived-inducible factor; Short=IL-TIF; Flags: Precursor, IL22, IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF, /evidence=ECO:0000269|PubMed:15340161., Interleukin-22. /id=PRO_0000015383., Interleukin 22 IL-10-related T-cell-derived-inducible factor; pfam14565, /evidence=ECO:0000269|PubMed:18599299., /evidence=ECO:0007829|PDB:3DLQ., /evidence=ECO:0007829|PDB:3DLQ., N-linked (GlcNAc...) asparagine. /evidence=ECO:0000269|PubMed:15983417., N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255., /evidence=ECO:0007829|PDB:1M4R., /evidence=ECO:0007829|PDB:3DLQ., /evidence=ECO:0007829|PDB:3DLQ., /evidence=ECO:0007829|PDB:3DLQ., /evidence=ECO:0000269|PubMed:18599299., N-linked (GlcNAc...) asparagine. /evidence=ECO:0000269|PubMed:15983417., /evidence=ECO:0007829|PDB:3DLQ., /evidence=ECO:0007829|PDB:3DLQ., /evidence=ECO:0007829|PDB:3DLQ., /evidence=ECO:0007829|PDB:3DLQ., /evidence=ECO:0007829|PDB:3DLQ., S -> G (in dbSNP:rs2227507). /evidence=ECO:0000269|Ref.5. /id=VAR_013078., /evidence=ECO:0007829|PDB:3DLQ. | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 精製 | Purified by antigen affinity column. | ||||||
| アクセッション番号 | Q9GZX6 | ||||||
| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||||
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||||
| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 背景 | Interleukin-22 (Interleukin-22,Cytokine Zcyto18,IL-22,ZCYTO18,IL22,ILTIF,IL-TIF,IL-10-related T-cell-derived-inducible factor) is a ~20 kDa protein. Cytokine that plays a critical role in modulating tissue responses during inflammation. Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage. Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. 1. Brand, S. et al. (2007) American journal of physiology. Gastrointestinal and liver physiology 292, G1019-28. PMID: 17204547 2. Xie, MH. et al. (2000) The Journal of biological chemistry 275, 31335-9. PMID: 10875937 3. Jones, BC. et al. (2008) Structure (London, England : 1993) 16, 1333-44. PMID: 18599299 4. Akil, H. et al. (2015) PloS one 10, e0119872. PMID: 25793261 5. Moniruzzaman, M. et al. (2019) International journal of molecular sciences 20. PMID: 31311100 | ||||||
| 注意事項 | For research use only. |
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