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Anti-Human beta-1 Adrenergic R/ADRB1 Recombinant Antibody (17.2) (HY486023)

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Vista general
Número de catálogoHY486023
Descripción
Anti-Human beta-1 Adrenergic R/ADRB1 Recombinant Antibody (17.2) (HY486023) is a mouse monoclonal antibody detecting beta-1 Adrenergic R/ADRB1 in ELISA, FCM, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, FCM, WB
Especie huéspedMouse
ClonalidadMonoclonal
IsotipoIgG2a
ID de clon17.2
Objetivo P08588
Nivel de endotoxinas < 10 EU/mg as determined by LAL method.
Pureza >95% as determined by SDS-PAGE.
Purificación Protein A/G purified from cell culture supernatant.
Número de acceso P08588
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:2000-1:20000
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Beta-1 adrenergic receptor (ADRB1) is a ~51 kDa protein. G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway. Binds epinephrine and norepinephrine with approximately equal affinity. Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2. As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac functions such as stimulation of cardiomyocyte contraction. Also delivers proapoptotic signals in cardiomyocytes.

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2. Pak, Y. et al. (2002) Molecular and cellular biology 22, 7942-52. PMID: 12391161
3. He, J. et al. (2004) The Journal of biological chemistry 279, 50190-6. PMID: 15358775
4. Xu, X. et al. (2021) Cell research 31, 569-579. PMID: 33093660
5. Börjesson, M. et al. (2000) European heart journal 21, 1853-8. PMID: 11052857
6. Ranade, K. et al. (2002) American journal of human genetics 70, 935-42. PMID: 11854867
7. Shi, G. et al. (2019) Neuron 103, 1044-1055.e7. PMID: 31473062
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human beta-1 Adrenergic R/ADRB1 Recombinant Antibody (17.2)

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