

| Numéro de catalogue | HY486023 | ||||||
|---|---|---|---|---|---|---|---|
| Description |
Anti-Human beta-1 Adrenergic R/ADRB1 Recombinant Antibody (17.2) (HY486023) is a mouse monoclonal antibody detecting beta-1 Adrenergic R/ADRB1 in ELISA, FCM, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||
| Applications | ELISA, FCM, WB | ||||||
| Espèce hôte | Mouse | ||||||
| Clonalité | Monoclonal | ||||||
| Isotype | IgG2a | ||||||
| ID de clone | 17.2 | ||||||
| Cible | P08588 | ||||||
| Niveau d'endotoxines | < 10 EU/mg as determined by LAL method. | ||||||
| Pureté | >95% as determined by SDS-PAGE. | ||||||
| Purification | Protein A/G purified from cell culture supernatant. | ||||||
| Numéro d'accès | P08588 | ||||||
| Forme | Liquid | ||||||
| Tampon de stockage | 0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| Contexte | Beta-1 adrenergic receptor (ADRB1) is a ~51 kDa protein. G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway. Binds epinephrine and norepinephrine with approximately equal affinity. Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2. As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac functions such as stimulation of cardiomyocyte contraction. Also delivers proapoptotic signals in cardiomyocytes. 1. Mason, DA. et al. (1999) The Journal of biological chemistry 274, 12670-4. PMID: 10212248 2. Pak, Y. et al. (2002) Molecular and cellular biology 22, 7942-52. PMID: 12391161 3. He, J. et al. (2004) The Journal of biological chemistry 279, 50190-6. PMID: 15358775 4. Xu, X. et al. (2021) Cell research 31, 569-579. PMID: 33093660 5. Börjesson, M. et al. (2000) European heart journal 21, 1853-8. PMID: 11052857 6. Ranade, K. et al. (2002) American journal of human genetics 70, 935-42. PMID: 11854867 7. Shi, G. et al. (2019) Neuron 103, 1044-1055.e7. PMID: 31473062 | ||||||
| Note | For research use only. |




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