

| Каталожный номер | HB791036 |
|---|---|
| Описание |
Anti-Human IL-1 RI Reference Antibody (Tesrakitug, RUO) (HB791036) is a human monoclonal antibody detecting IL-1 RI.
|
| Реактивность видов | Human |
| Применения | ELISA, FACS, Functional assay |
| Хозяинский вид | Human |
| Клоональность | Monoclonal |
| Изотип | IgG2, kappa |
| Цель | CD121 antigen-like family member A, CD121a, EC:3.2.2.6, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, IL1R, IL1R1, IL1RA, IL1RT1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, Interleukin-1 receptor type 1, membrane form, Interleukin-1 receptor type 1, soluble form, Interleukin-1 receptor type I, mIL-1R1, mIL-1RI, p80, sIL-1R1, sIL-1RI |
| Уровень эндотоксинов | < 10 EU/mg |
| Чистота | >95% as determined by SDS-PAGE. |
| Очистка | Protein A/G purified from cell culture supernatant. |
| Номер доступа | P14778 |
| Форма | Liquid |
| Буфер хранения | 0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt.. |
| Альтернативные названия | CAS: 3078753-82-6 |
| Фон | Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. 1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091 2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 37315560 3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850 |
| Примечание | For research use only. |




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