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Anti-Human CD121a/IL1R1 Recombinant Antibody (15C4) (HB791207)

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Anti-Human CD121a/IL1R1 Recombinant Antibody (15C4)

Anti-Human CD121a/IL1R1 Recombinant Antibody (15C4)

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Overview

Catalog No.	HB791207
Description	Anti-Human CD121a/IL1R1 Antibody (15C4) [15C4] (HB791207) is a mouse monoclonal antibody detecting CD121a in ELISA, FCM, IF, IHC, SPR, WB. Suitable for Human and Monkey. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human, Monkey
Applications	ELISA, FCM, IF, IHC, SPR, WB
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	15C4
Clonality	Monoclonal
Target	IL-1RT1, IL-1R-alpha, mIL-1R1, CD121a, IL-1R-1, sIL-1RI, IL1RT1, IL1R1, sIL-1R1, IL1R, CD121 antigen-like family member A, Interleukin-1 receptor type I, Interleukin-1 receptor alpha, mIL-1RI, IL1RA, IL-1RT-1, Interleukin-1 receptor type 1, p80
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P14778
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. 1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091 2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 37315560 3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
Note	For research use only.

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SDS-PAGE for Anti-Human CD121a/IL1R1 Antibody (15C4)

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Datasheet

Anti-Human CD121a/IL1R1 Recombinant Antibody (15C4).pdf

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Anti-Human CD121a/IL1R1 Recombinant Antibody (15C4)