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Anti-Human FCGRT/FCRN Antibody (SAA0136) (HX061207)

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Anti-Human FCGRT/FCRN Antibody (SAA0136)

Anti-Human FCGRT/FCRN Antibody (SAA0136)

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개요
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참고 문헌
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개요

카탈로그 번호	HX061207
설명	Anti-Human FCGRT/FCRN Antibody (SAA0136) [SAA0136] (HX061207) is a human monoclonal antibody detecting FCGRT in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
종 반응성	Human
응용 분야	FCM
숙주 종	Human
이소타입	IgG4, kappa
클론 ID	SAA0136
클론성	Monoclonal
타겟	IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, FcRn, FCGRT, FCRN, Neonatal Fc receptor
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P55899
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
배경	IgG receptor FcRn large subunit p51 (FCGRT) is a ~39 kDa protein. Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. 1. West, AP. et al. (2000) Biochemistry 39, 9698-708. PMID: 10933786 2. Story, CM. et al. (1994) The Journal of experimental medicine 180, 2377-81. PMID: 7964511 3. Mikulska, JE. et al. (2000) European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 27, 231-40. PMID: 10998088 4. Oganesyan, V. et al. (2014) The Journal of biological chemistry 289, 7812-24. PMID: 24469444 5. Pyzik, M. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2862-E2871. PMID: 28330995
참고사항	For research use only.

이미지

SDS-PAGE

SDS-PAGE for Anti-Human FCGRT/FCRN Antibody (SAA0136)

참고 문헌

데이터시트

Anti-Human FCGRT/FCRN Antibody (SAA0136).pdf

Formula

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Anti-Human FCGRT/FCRN Antibody (SAA0136)