Anti-Mouse CD5 Recombinant Antibody (YTS 121.5.2) (MY046107)

Name: Anti-Mouse CD5 Recombinant Antibody (YTS 121.5.2)
Brand: abinScience
SKU: MY046107
Price: 191 USD
Availability: InStock

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Каталожный номер	MY046107
Описание	Anti-Mouse CD5 Recombinant Antibody (YTS 121.5.2) (MY046107) is a rat monoclonal antibody detecting CD5 in FCM. Suitable for Mouse. Highlights ●Affinity Purified — Minimal background and high purity for reliable results.
Реактивность видов	Mouse
Применения	FCM
Хозяинский вид	Rat
Клоональность	Monoclonal
Изотип	IgG2b
ID клона	YTS 121.5.2
Цель	CD5, Cd5, Ly-1, Lymphocyte antigen 1, Lyt-1, T-cell surface glycoprotein CD5
Уровень эндотоксинов	< 10 EU/mg as determined by LAL method.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P13379
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	T-cell surface glycoprotein CD5 (Lymphocyte antigen T1/Leu-1,CD5,T-cell surface glycoprotein CD5,LEU1) is a ~54 kDa protein. Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. 1. Burgess, KE. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 9311-5. PMID: 1384049 2. Osman, N. et al. (1992) European journal of immunology 22, 2995-3000. PMID: 1385158 3. Roa, NS. et al. (2013) Biochemical and biophysical research communications 432, 52-9. PMID: 23376399 4. Garaud, S. et al. (2018) Cellular & molecular immunology 15, 158-170. PMID: 27499044
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse CD5 Recombinant Antibody (YTS 121.5.2).pdf

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Anti-Mouse CD5 Recombinant Antibody (YTS 121.5.2) (MY046107)

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