Mouse Anti-Human PMEL17/ME20M Antibody (17A9) (HW380107)

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개요
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개요

카탈로그 번호	HW380107
설명	Mouse Anti-Human PMEL17/ME20M Antibody (17A9) [17A9] (HW380107) is a mouse monoclonal antibody detecting ME20M in ELISA, FCM, IHC. Suitable for Human, Mouse, Rat, and Monkey. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications. ●Multi-Species — Cross-reactive for translational research.
종 반응성	Human, Mouse, Rat, Monkey
응용 분야	ELISA, FCM, IHC
숙주 종	Mouse
이소타입	IgG2a, kappa
클론 ID	17A9
클론성	Monoclonal
타겟	ME20M, Melanocyte protein PMEL, Silver locus protein homolog, Secreted melanoma-associated ME20 antigen, D12S53E, 95 kDa melanocyte-specific secreted glycoprotein, SILV, P100, Premelanosome protein, PMEL17, ME20S, PMEL, ME20-S, ME20-M, P26, P1, Melanocytes lineage-specific antigen GP100, Melanocyte protein Pmel 17, Melanoma-associated ME20 antigen
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P40967
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.09% Sodium azide. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
배경	Melanocyte protein PMEL (PMEL17/ME20M) is a ~70 kDa protein. Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway.
참고사항	For research use only.

이미지

Western blot

Western blot analysis was performed using anti-PMEL monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human PMEL (Catalog No: HW380012)
Lane 2: negative control
Bioactivity

Detects recombinant human PMEL (Catalog No: HW380012) in indirect ELISA

참고 문헌

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Mouse Anti-Human PMEL17/ME20M Antibody (17A9).pdf

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어세이 키트

Mouse Anti-Human PMEL17/ME20M Antibody (17A9) (HW380107)

개요

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참고 문헌

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