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Anti-Human TREM2 Antibody (SAA0548), PerCP (HV166147)

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개요

카탈로그 번호	HV166147
설명	Anti-Human TREM2 Antibody (SAA0548), PerCP [SAA0548] (HV166147) is a mouse monoclonal antibody detecting TREM2 in FCM, IF. Suitable for Human and Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
종 반응성	Human, Mouse
응용 분야	FCM, IF
숙주 종	Mouse
이소타입	IgG1, kappa
클론 ID	SAA0548
접합	PerCP
클론성	Monoclonal
타겟	Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2, TREM-2, TREM2
내독소 수준	Please contact with the lab for this information.
등록번호	Q9NZC2
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	Triggering receptor expressed on myeloid cells 2 (TREM2) is a ~25 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin. 1. Bouchon, A. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4991-5. PMID: 10799849 2. Yeh, FL. et al. (2016) Neuron 91, 328-40. PMID: 27477018 3. Zhao, Y. et al. (2018) Neuron 97, 1023-1031.e7. PMID: 29518356 4. Sudom, A. et al. (2018) The Journal of biological chemistry 293, 12634-12646. PMID: 29794134 5. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881 6. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066 7. Bouchon, A. et al. (2001) The Journal of experimental medicine 194, 1111-22. PMID: 11602640 8. Paloneva, J. et al. (2003) The Journal of experimental medicine 198, 669-75. PMID: 12925681
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human TREM2 Antibody (SAA0548), PerCP.pdf

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Anti-Human TREM2 Antibody (SAA0548), PerCP