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Anti-Human CALCRL Antibody (SAA0150), PE (HS841127)

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개요

카탈로그 번호	HS841127
설명	Anti-Human CALCRL Antibody (SAA0150), PE [SAA0150] (HS841127) is a human monoclonal antibody detecting CALCRL in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
종 반응성	Human
응용 분야	FCM
숙주 종	Human
이소타입	IgG2, lambda
클론 ID	SAA0150
접합	PE
클론성	Monoclonal
타겟	CGRP type 1 receptor, CGRPR, Calcitonin receptor-like receptor, CALCRL, Calcitonin gene-related peptide type 1 receptor
내독소 수준	Please contact with the lab for this information.
등록번호	Q16602
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	Calcitonin gene-related peptide type 1 receptor (CALCRL) is a ~52 kDa protein. G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. 1. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767 2. Josephs, TM. et al. (2021) Science (New York, N.Y.) 372. PMID: 33602864 3. Aiyar, N. et al. (1996) The Journal of biological chemistry 271, 11325-9. PMID: 8626685 4. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CALCRL Antibody (SAA0150), PE.pdf

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Anti-Human CALCRL Antibody (SAA0150), PE