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| 카탈로그 번호 | VK565080 |
|---|---|
| 설명 |
InVivoMAb Anti-SARS-CoV-2 RBD Antibody (PR1077) [PR1077] (VK565080) is a human monoclonal antibody detecting Spike glycoprotein in ELISA, Neutralization. Suitable for SARS-CoV-2.
|
| 종 반응성 | SARS-CoV-2 |
| 응용 분야 | ELISA, Neutralization |
| 숙주 종 | Human |
| 이소타입 | IgG1 |
| 클론 ID | PR1077 |
| 클론성 | Monoclonal |
| 타겟 | Spike glycoprotein, S glycoprotein, E2, Peplomer protein, RBD, Spike protein S1, S, Receptor-Binding Domain, S 6P trimer, SARS-CoV-2 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P0DTC2 |
| RRID | InVivoMAb Anti-SARS-CoV-2 RBD Antibody (PR1077) (abinScience Cat# VK565080, RRID:AB_3729304) |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Spike glycoprotein (RBD) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for InVivoMAb Anti-SARS-CoV-2 RBD Antibody (PR1077)
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