



| Каталожный номер | AY583093 |
|---|---|
| Описание |
Anti-Sarilumab Neutralizing Recombinant Antibody (SAA2884) (AY583093) is a mouse monoclonal antibody detecting Sarilumab in ELISA. Suitable for General.
Highlights
|
| Реактивность видов | General |
| Применения | ELISA |
| Хозяинский вид | Mouse |
| Клоональность | Monoclonal |
| Изотип | IgG1 |
| ID клона | SAA2884 |
| Иммуноген | Sarilumab |
| Уровень эндотоксинов | < 10EU/mg |
| Чистота | >95% as determined by SDS-PAGE. |
| Очистка | Protein A/G purified from cell culture supernatant. |
| Номер доступа | CAS: 1189541-98-7 |
| Форма | Liquid |
| Буфер хранения | 0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Фон | Interleukin-6 receptor subunit alpha (Sarilumab) is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. 1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003 2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492 3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509 |
| Примечание | For research use only. |

Detects Sarilumab (Catalog No: HY583016) in indirect ELISA.

Blocks the binding of Sarilumab to IL6R.




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