홈 > 제품 > 항체 > 바이오시밀러

Research Grade Sarilumab (HY583016)

데이터시트 제품 공유 정보 복사

Research Grade Sarilumab

Research Grade Sarilumab

Research Grade Sarilumab

Research Grade Sarilumab

Research Grade Sarilumab

Research Grade Sarilumab

Research Grade Sarilumab

Research Grade Sarilumab

가격(USD): $

사양:

100ug
1mg

수량:

문의하기

개요
이미지
참고 문헌
데이터시트

개요

카탈로그 번호	HY583016
설명	Sarilumab (HY583016) is a research-grade recombinant antibody targeting CD126. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
이소타입	IgG1-kappa
발현 시스템	Mammalian Cells
클론성	Monoclonal
타겟	sIL6R, Interleukin-6 receptor subunit alpha, CD126, IL-6R 1, IL-6R subunit alpha, Membrane glycoprotein 80, gp80, IL6R, IL-6RA, IL-6 receptor subunit alpha, IL-6R-alpha
내독소 수준	Please contact the lab for this information.
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P08887
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
대체 이름	REGN88, SAR153191, 1189541-98-7
배경	Interleukin-6 receptor subunit alpha (CD126/IL6R) is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. 1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003 2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492 3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509
참고사항	For research use only. Not suitable for clinical or therapeutic use.

이미지

SEC-HPLC

SEC-HPLC detection for Research Grade Sarilumab.
Bioactivity

Detects Human CD126/IL6R/IL-6RA in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Sarilumab.
Western blot

Western blot analysis was performed using anti-CD126/IL6RA monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD126/IL6RA (Catalog No: HY583011)
Lane 2: negative control

참고 문헌

데이터시트

Research Grade Sarilumab.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

=

Concentration

×

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

×

V₁ (Stock Vol.)

=

Working Solution

C₂ (Working Conc.)

×

V₂ (Working Vol.)

추천

문의하기 맞춤형 견적, 대량 주문 및 기타 문의 사항은

메일: support@abinScience.com

배급사 목록

Research Grade Sarilumab