Research Grade Anti-Human FAP/FAPalpha (NG-641) (HC440036)

데이터시트 제품 공유 정보 복사

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사양:

100ug
1mg

수량:

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개요
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데이터시트

개요

카탈로그 번호	HC440036
설명	Anti-Human FAP/FAPalpha (NG-641) (HC440036) is a research-grade recombinant antibody targeting Surface-expressed protease. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
이소타입	IgG
클론 ID	NG-641
발현 시스템	Mammalian Cells
클론성	Monoclonal
타겟	Surface-expressed protease, Gelatine degradation protease FAP, Integral membrane serine protease, Dipeptidyl peptidase FAP, Seprase, FAP, Post-proline cleaving enzyme, APCE, SIMP, FAPalpha, 170 kDa melanoma membrane-bound gelatinase, Fibroblast activation protein alpha, Serine integral membrane protease, Prolyl endopeptidase FAP
내독소 수준	Please contact the lab for this information.
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q12884
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
대체 이름	NG-641, NG641, NG641
배경	Prolyl endopeptidase FAP (FAPalpha) is a ~87 kDa protein. Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vitronectin, tenascin, laminin, fibronectin, fibrin or casein. Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB). 1. Lee, KN. et al. (2004) Blood 103, 3783-8. PMID: 14751930 2. Lee, KN. et al. (2006) Blood 107, 1397-404. PMID: 16223769 3. Edosada, CY. et al. (2006) The Journal of biological chemistry 281, 7437-44. PMID: 16410248 4. Edosada, CY. et al. (2006) FEBS letters 580, 1581-6. PMID: 16480718 5. Meadows, SA. et al. (2007) Biochemistry 46, 4598-605. PMID: 17381073 6. Aggarwal, S. et al. (2008) Biochemistry 47, 1076-86. PMID: 18095711 7. Huang, CH. et al. (2011) Journal of biochemistry 149, 685-92. PMID: 21288888 8. Keane, FM. et al. (2013) FEBS open bio 4, 43-54. PMID: 24371721 9. Levy, MT. et al. (1999) Hepatology (Baltimore, Md.) 29, 1768-78. PMID: 10347120 10. Mueller, SC. et al. (1999) The Journal of biological chemistry 274, 24947-52. PMID: 10455171
참고사항	For research use only. Not suitable for clinical or therapeutic use.