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| 카탈로그 번호 | HV243016 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 이소타입 | IgG2-lambda |
| 발현 시스템 | Mammalian Cells |
| 종 | Human |
| 클론성 | Monoclonal |
| 타겟 | TSLP, Thymic stromal lymphopoietin |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q969D9 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 대체 이름 | AMG 157, AMG-157, MEDI-9929, MEDI9929, anti-TSLP-Receptor (TSLP-R, Crl2), 1572943-04-4 |
| 배경 | Tezepelumab is a first-in-class human monoclonal antibody that binds to TSLP, thus inhibiting its interaction with TSLP receptor complex. Tezepelumab given as an add-on-therapy to patients with severe uncontrolled asthma has shown safety, tolerability and efficacy. Several trials are evaluating the long-term safety and the efficacy of tezepelumab in adults and adolescents with severe uncontrolled asthma. • Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay with the Epithelium in Allergy and Asthma., PMID:37628907 • Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma., PMID:32567399 • Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD., PMID:36697211 • Role of thymic stromal lymphopoietin in allergy and beyond., PMID:35650271 • IL-31-generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin., PMID:36410530 • Serum thymic stromal lymphopoietin (TSLP) levels in atopic dermatitis patients: a systematic review and meta-analysis., PMID:37515689 • Thymic Stromal Lymphopoietin and Tezepelumab in Airway Diseases: From Physiological Role to Target Therapy., PMID:38892164 • Investigational thymic stromal lymphopoietin inhibitors for the treatment of asthma: a systematic review., PMID:38206116 • Pathogenesis of allergic diseases and implications for therapeutic interventions., PMID:36964157 • Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis., PMID:37500310 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
Detects TSLP in indirect ELISAs.
SDS-PAGE for Research Grade Tezepelumab.
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