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| カタログ番号 | MV986022 |
|---|---|
| 説明 |
Recombinant Mouse GDF15 Protein, N-His (MV986022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9Z0J7 |
| タンパク質長 | Ser189-Ala303 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | GDF-15, Gdf15, Growth/differentiation factor 15, MIC-1, Macrophage inhibitory cytokine 1, Mic1, Sbf |
| 背景 | Growth/differentiation factor 15 is a ~33 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues. 1. Tsai, VW. et al. (2013) PloS one 8, e55174. PMID: 23468844 2. Chung, HK. et al. (2017) The Journal of cell biology 216, 149-165. PMID: 27986797 3. Wang, T. et al. (2017) EMBO molecular medicine 9, 1150-1164. PMID: 28572090 4. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097 5. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098 6. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099 7. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886 8. Tsai, VW. et al. (2018) International journal of obesity (2005) 42, 561-571. PMID: 29026214 9. Xiong, Y. et al. (2017) Science translational medicine 9. PMID: 29046435 10. Patel, S. et al. (2019) Cell metabolism 29, 707-718.e8. PMID: 30639358 |
| 注意事項 | For research use only |
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