Anti-Mouse GDF15/MIC1 Polyclonal Antibody (MV986014)

Name: Anti-Mouse GDF15/MIC1 Polyclonal Antibody
Brand: abinScience
SKU: MV986014
Price: 96 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

MV986014

Species reactivity

Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse GDF15/MIC1 (Gly203-Ala303).

Target

Growth/differentiation factor 15, GDF-15, Macrophage inhibitory cytokine 1, MIC-1

Purification

Purified by antigen affinity column.

Accession

Q9Z0J7

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Growth/differentiation factor 15 (GDF15/MIC1) is a ~33 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues.

1. Tsai, VW. et al. (2013) PloS one 8, e55174. PMID: 23468844

2. Chung, HK. et al. (2017) The Journal of cell biology 216, 149-165. PMID: 27986797

3. Wang, T. et al. (2017) EMBO molecular medicine 9, 1150-1164. PMID: 28572090

4. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

5. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

6. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

7. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

8. Tsai, VW. et al. (2018) International journal of obesity (2005) 42, 561-571. PMID: 29026214

9. Xiong, Y. et al. (2017) Science translational medicine 9. PMID: 29046435

10. Patel, S. et al. (2019) Cell metabolism 29, 707-718.e8. PMID: 30639358

Note

For research use only.

Images

References

Datasheet

Anti-Mouse GDF15/MIC1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Mouse GDF15/MIC1 Polyclonal Antibody (MV986014)

Overview

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Datasheet

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