Mouse GDF15 Recombinant Protein (N-His) (MV986022)

Name: Mouse GDF15 Recombinant Protein (N-His)
Brand: abinScience
SKU: MV986022
Price: 211 USD
Availability: InStock

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Catalog No.	MV986022
Description	Recombinant Mouse GDF15 Protein, N-His (MV986022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q9Z0J7
Protein length	Ser189-Ala303
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	GDF-15, Gdf15, Growth/differentiation factor 15, MIC-1, Macrophage inhibitory cytokine 1, Mic1, Sbf
Background	Growth/differentiation factor 15 is a ~33 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues. 1. Tsai, VW. et al. (2013) PloS one 8, e55174. PMID: 23468844 2. Chung, HK. et al. (2017) The Journal of cell biology 216, 149-165. PMID: 27986797 3. Wang, T. et al. (2017) EMBO molecular medicine 9, 1150-1164. PMID: 28572090 4. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097 5. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098 6. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099 7. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886 8. Tsai, VW. et al. (2018) International journal of obesity (2005) 42, 561-571. PMID: 29026214 9. Xiong, Y. et al. (2017) Science translational medicine 9. PMID: 29046435 10. Patel, S. et al. (2019) Cell metabolism 29, 707-718.e8. PMID: 30639358
Note	For research use only

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Mouse GDF15 Recombinant Protein (N-His).pdf

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Mouse GDF15 Recombinant Protein (N-His) (MV986022)

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