Anti-Mouse GDF15 Recombinant Antibody (mAB2) (MV986013)

Name: Anti-Mouse GDF15 Recombinant Antibody (mAB2)
Brand: abinScience
SKU: MV986013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

MV986013

Description

Anti-Mouse GDF15 Recombnant Antibody (mAB2) (MV986013) is a mouse monoclonal antibody detecting GDF-15 in ELISA, Neutralization. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, Neutralization

Host species

Mouse

Clonality

Monoclonal

Isotype

IgG1 (D265A), kappa

Clone ID

mAB2

Target

GDF-15, GDF15, Growth/differentiation factor 15, MIC-1, MIC1, Macrophage inhibitory cytokine 1, NAG-1, NRG-1, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, PDF, PLAB, PTGFB, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9Z0J7

Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Growth/differentiation factor 15 (GDF15/MIC1) is a ~34 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues.

1. Tsai, VW. et al. (2013) PloS one 8, e55174. PMID: 23468844

2. Tsai, VW. et al. (2014) PloS one 9, e100370. PMID: 24971956

3. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097

4. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098

5. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099

6. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886

7. Xiong, Y. et al. (2017) Science translational medicine 9. PMID: 29046435

8. Patel, S. et al. (2019) Cell metabolism 29, 707-718.e8. PMID: 30639358

9. Coll, AP. et al. (2020) Nature 578, 444-448. PMID: 31875646

10. Klein, AB. et al. (2021) Nature communications 12, 1041. PMID: 33589633

Note

For research use only.

Images

References

Datasheet

Anti-Mouse GDF15 Recombinant Antibody (mAB2).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse GDF15 Recombinant Antibody (mAB2) (MV986013)

Overview

Images

References

Datasheet

SDS