Anti-Human IFN-gamma Recombinant Nanobody (SAA2798) (HF813033)

Name: Anti-Human IFN-gamma Recombinant Nanobody (SAA2798)
Brand: abinScience
SKU: HF813033
Price: 191 USD
Availability: InStock

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Цена(USD):

Спецификация:

50ug
100ug
1mg

Количество:

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Обзор
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Ссылки
Даташит
SDS

Обзор

Каталожный номер

HF813033

Описание

Anti-Human IFN-gamma Recombinant Nanobody (SAA2798) (HF813033) is a alpaca monoclonal antibody detecting IFN-gamma in ELISA, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, WB

Хозяинский вид

Alpaca

Клоональность

Monoclonal

Изотип

VHH-8His-Cys-tag

ID клона

SAA2798

Проверенные приложения

Цель

IFN-gamma, IFNG, Immune interferon, Interferon gamma

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Purified by Nickel column

Номер доступа

P01579

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Реконституция

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Interferon gamma (Interferon gamma,IFN-gamma,Immune interferon,IFNG) is a ~19 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.

1. El Bougrini, J. et al. (2006) Cellular and molecular biology (Noisy-le-Grand, France) 52, 9-15. PMID: 16914093

2. Hisamatsu, H. et al. (1996) The Journal of experimental medicine 183, 1807-16. PMID: 8666937

3. Greenlund, AC. et al. (1993) The Journal of biological chemistry 268, 18103-10. PMID: 8349687

4. Akiyama, K. et al. (1994) FEBS letters 343, 85-8. PMID: 8163024

5. Fabunmi, RP. et al. (2001) Journal of cell science 114, 29-36. PMID: 11112687

6. Lah, TT. et al. (1995) FEBS letters 363, 85-9. PMID: 7729559

Примечание

For research use only

Изображения