Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Nanobody, C-Sortase tag (SAA2049) (HW717023)

Name: Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Nanobody, C-Sortase tag (SAA2049)
Brand: abinScience
SKU: HW717023
Price: 191 USD
Availability: InStock

Даташит Поделиться продуктом Копировать информацию

Цена(USD):

Спецификация:

50ug
100ug
1mg

Количество:

Свяжитесь с нами

Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HW717023

Описание

Anti-Human CD27 Ligand/TNFSF7/CD70 Recombinant Nanobody, C-Sortase tag (SAA2049) (HW717023) is a alpaca monoclonal antibody detecting CD27 Ligand/TNFSF7/CD70 in ELISA, FCM. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, FCM

Хозяинский вид

Alpaca

Клоональность

Monoclonal

Изотип

VHH-Sortase Tag-6His

ID клона

SAA2049

Цель

CD27 ligand, CD27-L, CD27L, CD27LG, CD70, CD70 antigen, TNFSF7, Tumor necrosis factor ligand superfamily member 7

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Purified by Nickel column

Номер доступа

P32970

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Реконституция

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

CD27 antigen is a ~29 kDa protein. Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue.

1. Izawa, K. et al. (2017) The Journal of experimental medicine 214, 73-89. PMID: 28011863

2. Jaeger-Ruckstuhl, CA. et al. (2024) Immunity 57, 287-302.e12. PMID: 38354704

Примечание

For research use only

Изображения